Funding Opportunity! John S. Dunn Gulf Coast Consortium for Chemical Genomics/R. A. Welch Foundation Chemistry and Biology Collaborative Grants
John S. Dunn Gulf Coast Consortium for Chemical Genomics
R. A. Welch Foundation Chemistry and Biology Collaborative Grants
Request for Applications
Letter of Intent: May 1, 2008
Preproposal: June 1, 2008
Final Proposal (by invitation based on Preproposal): July 15, 2008
The John S. Dunn GCC for Chemical Genomics (GCC CG) was organized in 2003 to address the growing need among investigators at the GCC Institutions (Baylor College of Medicine, UT M. D. Anderson Cancer Center, Rice University, University of Houston, UT Medical Branch at Galveston, UT Health Science Center at Houston) for a centralized capability to support high-throughput screening research. The goal of the program is (1) to provide the infrastructure to support new research programs that will lead to the identification of molecular targets for the treatment of disease and (2) once targets are identified, to facilitate the assembly of teams of chemists and biologists who can work together to discover new drug-like small molecules that can impact these targets and serve as leads for the development of novel agents for the treatment of disease.
Previous support generously provided by theJohn S. Dunn Foundation has been targeted largely towards the development of the "biology" side of the Chemical Genomics Program. This support has included resources to purchase the robotic equipment and siRNA libraries necessary to support high-throughput screening projects as well as funds for pilot grants to launch new screening projects and drug discovery programs.
Now, with the generous support of The Welch Foundation, we are in position to expand the Dunn Chemical Genomics Program by providing support for the "chemistry" side of the program. The Welch Foundation is providing funding for research projects designed to advance our understanding of the optimal ways of applying computational and synthetic chemistry to chemical genomics. It is important to emphasize that the goal of this program is to support research projects that will provide new insights into the most effective ways that computational and synthetic chemistry can be combined with high-throughput screening strategies to improve the selection of leads for target-based drug discovery. The goal of this program is not to support the application of established methods of computational and synthetic chemistry to biological problems, rather the goal is to explore novel chemical approaches, both computational and synthetic, that may be used to advance the field of chemical genomics.
In order to implement this new program of chemical research, the Dunn GCC for Chemical Genomics is establishing a Chemistry Core within the Consortium. This Chemistry Core will serve as a resource for coordinating the development and implementation of research projects designed to advance our understanding of the application of computational and synthetic chemistry to chemical genomics research. Membership in this Chemistry Core will be selected from faculty members from the GCC institutions (or, by invitation, from other academic institutions in Texas) with qualifications and expertise in the fields of computational and synthetic chemistry. A committee of Chemistry Core members will review and approve proposals for funding, via seed grants (R. A. Welch Foundation Chemistry and Biology Collaboration Grants) for collaborative projects between GCC chemists and biologists. These Welch Grants will enable researchers investigating biological problems to forge relationships with synthetic and computational chemists and gather the preliminary data required for successful applications for peer-reviewed funding and publication.
This announcement is to solicit proposals for the first round of the Welch Foundation Chemistry and Biology Collaboration Grants. For program goals, eligibility and application information, please visit John S. Dunn GCC for Chemical Genomics web site: