I have a history of depression. My whole family had it in one form or another. I was so relieved when SSRIs like Zoloft came on the market. I took Zoloft for years and went off it periodically but always "crashed" into depression when I quit. Just about the time I resigned myself to being a lifelong Zoloft patient, I was diagnosed with carcinoid of the small bowel. I quit taking everything anticipating the surgery which included tumor removal and small bowel resection. I read that some carcinoid specialists say to avoid SSRIs, including Zoloft. I have been prescribed Wellbutrin (150 mg/daily)and it works ok although it sometimes makes me jittery and I can't sleep without taking a sleep aid like Ambien. I sometimes take Chlorazepate (Tranxene) when the Wellbutrin causes my neck muscles to tighten painfully. Is there any way off this medical merry-go-round? I really would prefer to take less medicine. The psychiatrist I see says stay with what works. But I'm not sure it is working all that well.I sometimes get sad and weepy, especially when I am tired. Other times, I am not tired but still sad and weepy.