My daughter was diagnosed with Non-Hodgkins Lymphoma in 2005 when she was 24. She was given CHOP chemo and Rituxan for 6 treatments and then just Rituxan every 8 weeks for 5years and then last year her doctor switched her Rituxan treatments to every 12 weeks. She has been doing very well with this treatment. She is now 30 years old and thought that she would never have kids because of the chemo. Last week she found out she is pregnant. She is going to stop her treatments until after the baby is born. Our question is: What will the Rituxan that was already in her system do to an unborn baby? Thanks
Posted: 31 May 2011 10:24 AM Originally Posted: 31 May 2011 10:23 AM
Only a minimal amount of Rituximab crosses the placenta during the first trimester but more and more will cross as the pregnancy progresses so it is unlikely that the baby has been exposed to the Rituximab. Thirteen cases of Rituximab being given to pregnant women have been reported. Another 10 cases are mentioned in an unpublished safety report. All of the babies have been healthy and not had any deformities. In addition, studies in monkeys show no teratogenic effects of Rituximab.
Dr Andrea Milbourne, one of gynecologists here at MD Anderson, collects information on pregnant patients who are receiving therapy for their cancer when they get pregnant so we can collect data to help future women through their pregnancies.
Posted: 02 Jun 2011 09:26 AM Originally Posted: 02 Jun 2011 09:25 AM