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Subject:comparing medications

I have received Reclast and am due again in November. A friend said her doctor has recommend Prolia every 6 months. Are these 2 similiar?  She had a previous reaction to Atelvia.  Just wondering how these drugs compare and what is the lastest and best meds now for osteopenia.

Thank you.

Posted: 04 Oct 2011 03:30 PM
Originally Posted: 04 Oct 2011 03:31 PM
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Subject:comparing medications

Prolia (generic name Denosumab) is a new medication that is a subcutaneous (given just under the skin) injection every six months.  Although the end point that the medication effects is similar to Fosamax and like medications ie. Actonel, Boniva, Reclast, and Atelvia, to decrease bone loss and reduce fracture, they work through different mechanisms.


Our first line therapy, continues to be Fosamax and like medications (Actonel, Boniva, Reclast, Atelvia).  Denosumab is a good choice of medications for people who have any degree of kidney failure and prohibits them to use the other medications.


Their side effect profile will be different, but the most common rare side effect to Fosamax and like medications is Osteonecrosis of the Jaw (ONJ), this occurs with the same frequency in Prolia as in  Fosamax (and like medications).


Of note, Prolia is not FDA-approved for the treatment of "osteopenia."

Posted: 10 Oct 2011 09:41 AM
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