The UT-GSBS Program in Human and Molecular Genetics (HMG) brings together faculty with expertise in all areas of human and molecular genetics from several schools and institutions in the Texas Medical Center to participate in the education of graduate students interested in molecular and analytical aspects of human and molecular genetics. We are a diverse, interdisciplinary program of faculty involved in the unraveling of both the molecular lesions and the fundamental molecular mechanisms underlying the genetic components of biomedical disease. Areas of research include: Animal Models of Human Genetic Disease, Bioinformatics/Computational Genomics, Cancer Genetics, Complex Disease Genetics, Medical Genetics, and Molecular/Cellular Genetics

The program has over a 20-year history of training students to be independent researchers. Many of our alumni are making significant research contributions in academia, industry, or government organizations.

The Graduate School of Biomedical Sciences allows considerable flexibility in building an individualized curriculum. There are four GSBS Core Areas (Quantitative, Molecular, Cellular and Systems) from each of which most Program and non-Program doctoral students select and take at least one course. Students take additional elective courses to meet their individual and Program needs. The GSBS Program in Human & Molecular Genetics is a flexible Program that recognizes the diverse needs of its students by "recommending" rather than requiring the selection of particular courses. With the advent of a Written (Breadth) Candidacy Exam in Fall 2001 for the entering class of Fall 1999 however, we have revised the curriculum to include courses that we view as important for all doctoral students who affiliate with the Program. The Curriculum combines GSBS Core Area courses, with "strongly recommended" courses in Human and Molecular Genetics, and also with elective courses aimed at developing specialization relevant to the research area within Human and Molecular Genetics that is chosen by the student and her/his Advisor.

The courses that contain the material most needed to prepare for the HMG Program Written (Breadth) Exam part of the Ph.D. Candidacy Exam while satisfying required coursework in the four GSBS Core Areas are listed below:

Quantitative:

• GS010014 (Summer) Biomedical Statistics (if needed) and/or
• GS110013 (Fall) Genetics & Human Disease (strongly recommended)

Molecular:

• GS030014 (Fall) Metabolic Biochemistry (if required) and/or
• GS040123 (Spring) Eukaryotic Gene Expression (strongly recommended)

Cellular:

• GS040013 (Fall) Cell Biology (if required) and/or
• GS110023 (Spring) Molecular & Cellular Approaches to Humans Genetics (strongly recommended)

Systems:

• GS040063 (Fall) Cancer Biology (alternative) or
• GS040073 (Fall) Developmental Biology (alternative) or
• GS040203 (Fall) Experimental Genetics (alternative) or
• GS120254 (Spring) Cell & Systems Physiology (alternative)

Elective Courses Taught by the HMG Progam Faculty:

• GS110032 (Fall) Introduction to Genomics and Bioinformatics
• GS110033 (Spring) Methods in Genetic Epidemiology Linkage
• GS110042 (Spring) Population Genetics
• GS110043 (Spring) Molecular and Genetic Basis of Obesity
• GS110062 (Spring) Human DNA Variation (years 2005, 2007 etc.)
• GS110072 (Fall) Statistical Genetics (years 2004, 2006 etc.)
• GS110092 (Spring) Genetic Epidemiology of Chronic Disease
• GS110103 (Fall) Evolution of DNA and Protein Sequences (years 2005, 2007 etc.)
• GS110611 (Fall, Spring) Special Topics in Cytogenetics
• GS110711 (Fall, Spring) Seminar in Genetics and Population Biology
• PH2998 (Summer) Applied Genetic Methods in Public Health

Other Recommended Electives:

• GS010033 (Spring) Introductory Biostatistics & Bioinformatics
• GS010163 (Fall) Analysis of Microarray Data (years 2004, 2006 etc.)
• GS030090 (Fall) Introductory Biochemistry (if background weak/outdated)
• GS040133 (Spring) Cancer Cell Signaling
• GS060014 (Fall) Immunology I
• GS070014 (Fall) Microbiology and Molecular Genetics I

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