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Recently by Katrina Burton

Reitzel new 5.19.2013.jpgThe U.S. Centers for Disease Control and Prevention estimates obesity to be a contributing factor to millions of dollars in health care costs and anywhere from 100,000 to 400,000 deaths a year. Easy access to less healthy foods such as fast food has helped widen the gap between ethnic groups when it comes to body mass index (BMI), according to researchers at The University of Texas MD Anderson Cancer Center.

A study, published this week in the American Journal of Public Health, found African-American adults living close to a fast food restaurant are more likely to have a higher BMI than those living farther away. The study also found that those living within 2 miles of a fast food restaurant with income of $40,000 or less were strongly associated with having a higher BMI.

A person is considered overweight with a BMI between 25 and 29, and considered obese with a measurement of 30 and over. Current research shows that African-Americans experience the highest rate of obesity with 38.8 percent of black men being obese and 58.5 percent of black women being obese.

"In fact, African-American women have the highest rates of obesity compared to Caucasians and Hispanics in the U.S.," said Lorraine Reitzel, Ph.D., assistant professor in MD Anderson's Department of Health Disparities Research and lead investigator on the study. 

New approach helps more smokers connect to tobacco treatment

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144020_Irvin_Vidrine_J web.jpgSmoking remains the leading cause of preventable illness and death in the United States, so the health benefits of quitting are substantial. The majority of smokers are motivated to quit and more than half of all smokers attempt to quit each year. Sadly, only a small minority succeeds.

 

Researchers at MD Anderson are working to change this by changing the culture of how they reach self-admitted smokers with a new approach aimed at connecting through family practice clinics.

 

A collaboration involving MD Anderson researchers, the Texas Quitline and Kelsey-Seybold Clinics targeted smokers and their enrollment in tobacco treatment programs by directly connecting smokers with cessation quit lines.

 

Ask-Advise-Connect

 

Ask-Advise-Connect, a new approach designed to efficiently link smokers with cessation treatment, showed a significant increase in tobacco treatment enrollment by smokers who were directly contacted by quit line staff, according to results published online today in JAMA Internal Medicine

 

JAMA published a video interview Feb. 27 with study principal investigator Jennifer Irvin Vidrine, Ph.D., associate professor in the Department of Health Disparities Research at MD Anderson.

 

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Trusting neighbors and community may aid smoking cessation in African-American smokers, accordingly to a study published in the Annals of Behavioral Medicine, a publication of the Society of Behavioral Medicine.

MD Anderson researchers collected data from 397 African-Americans seeking treatment to quit smoking to determine if there was a significant relationship between social cohesion and smoking cessation. The study examined if social cohesion -- the self-reported connectedness and trust felt between neighbors -- was directly linked to smoking abstinence in African-American smokers actively trying to quit, and if psychosocial mediators played a role in those relations.

"We know from previous research that despite later smoking initiation and a lower rate of smoking, African-American smokers are more likely to develop smoking-related diseases and to die from them than are Caucasians," said Lorraine Reitzel, Ph.D., assistant professor in the Department of Health Disparities Research at MD Anderson Cancer Center.  "Investigating factors that affect smoking cessation within this population is important to increase our understanding of how to reduce smoking-related health disparities among this group."

More than 45,000 African-Americans die in the United States from smoking related cancers per year.

Pre-quit, quit-day and post-quit

Participants were followed over a six-month period during three stages of the study: pre-quit, quit-day and post-quit. During the first stage, data was collected on demographics including educational level and employment status, as well as tobacco dependence, so that known effects of these things on smoking cessation could be controlled for in the data analyses.

Wong-Ho Chow.JPGA grimmer prognosis awaits African-Americans when compared to Caucasian patients suffering from renal cell carcinoma (RCC), the most common form of invasive kidney cancer.

In a recent study lead at the National Cancer Institute and published in the Cancer journal, researchers found that African-Americans tend to have a poorer 5-year survival rate than Caucasians regardless of clinical data and patient demographics. "There is a consistent disparity between the races," said Wong-Ho Chow, Ph.D., professor in MD Anderson's Department of Epidemiology and lead investigator on the study.

In this study, clinical data and demographics of nearly 40,000 RCC patients diagnosed over a 15-year period from 12 registries in the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program, were analyzed.

The study revealed the 5-year relative survival rate for Caucasians diagnosed with invasive kidney cancer was 72.6% as compared to 68% for African-Americans regardless of age, sex, tumor size or stage, type of RCC and surgical procedures performed. SEER data also showed a poorer survival rate among men and older patients as compared to women and younger patients.

By Katrina Burton
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According to data from the National Cancer Institute's SEER database, less than 50% of patients with stage three bladder cancer will survive five years past their diagnosis.

Recent data presented at the11th Annual AACR International Conference on Frontiers in Cancer Prevention Research revealed shortened telomeres - a biomarker linked to aging - and depression significantly reduced bladder cancer patients' survival.

Telomeres are found on the tips of chromosomes and protect the chromosomes from damage, like the plastic tip on the end of a shoelace.  They shorten as cells divide, eventually causing lethal genomic damage to the cell. When damaged cells survive, they can promote cancer development.

The data collected from 464 patients enrolled in MD Anderson's ongoing epidemiology bladder cancer study, showed a significant increase in mortality for patients who had high levels of depressive symptoms as well as short telomeres.

On the other hand, patients with low levels of depression - as indicated by the Center for Epidemiologic Studies Depression Scale (CES-D) - and long telomeres lived longer. The study found a six-fold increase in survival for these bladder cancer patients - 31.3 months vs. 199.8 months. Those with short telomeres and high levels of depression had a three-fold risk of mortality.

"We anticipated a strong association with combined shortened telomere length and high levels of depressive symptoms," said lead investigator Meng Chen, Ph.D., instructor of MD Anderson's Department of Epidemiology. "Patients who aren't treated for depression tend to exhibit anxiety and stress that increases the shortening of the telomere process."

AACR: An annual meeting of "like minds" in cancer prevention

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By Katrina Burton
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One of the most collaborative meetings of researchers in basic, clinical, behavioral and epidemiological science focused on cancer prevention, the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, is taking place in Anaheim, CA, this week.

A plethora of professionals is expected to attend this year's conference, which focuses on scientific and lifestyle strategies to prevent cancer. With hundreds of research studies and lectures, the program lineup is sure to have something for not only scientists, but for patient advocates and survivors as well. 

MD Anderson Cancer Center will definitely represent with major presentations and leaders chairing sessions, including Ernest T. Hawk, M.D., vice president and head of the Division of Cancer Prevention and Population Sciences.

Past chair of the 2009 AACR International Conference on Frontiers in Cancer Prevention Research, Hawk continues to take a leadership role for this year's conference.

Hawk started off the program Tuesday morning with a professional advancement session for trainees on how to succeed in the field of cancer prevention. He chairs two sessions this week. The first focuses on prostate cancer screening, particularly highlighting the issues of overscreeening, overdiagnosis and overtreatment, and is the opening session Wednesday morning.

smokingdeclineimage.jpgBy Katrina Burton, MD Anderson Staff Writer

Tobacco use has long been known to cause lung cancer and increased morbidity in smokers. A study sponsored by the National Cancer Institute (NCI) recently revealed the positive impact of U.S.-initiated tobacco control policies and programs with the prevention of 795,000 lung cancer deaths from 1975 through 2000.

Researchers at MD Anderson and Rice University collaborated as one of six lung cancer modeling groups for the NCI-sponsored Cancer Intervention and Surveillance Modeling Network Consortium. They applied a comparative modeling approach in which detailed smoking histories of 30- to 84-year-olds born from 1890 to 1970 were related to lung cancer mortality in mathematical models.

Using these models, researchers analyzed the impact of changes in smoking patterns resulting from tobacco control activities initiated after the U.S. Surgeon General's Report on Smoking and Health was released in 1964.
By Katrina Burton, MD Anderson Staff Writer

At an early age, children are naturally physically active, full of energy and often find joy in running and jumping in an unstructured environment. However, as children transition to adolescence, physical activity levels tend to decline, particularly among girls. This is also a time when excess weight gain often occurs.

Physical inactivity and obesity are important risk factors for a variety of cancers, and behaviors developed during adolescence can persist into adulthood. Identifying factors that contribute to physical activity during this critical stage of development may help future efforts to promote continued activity among adolescents. Mexican-American adolescents exhibit an increased prevalence of obesity compared to other adolescent populations.

So what are the factors that influence physical activity and sedentary behaviors in Mexican-American adolescents? Researchers at MD Anderson Cancer Center's Division of Cancer Prevention and Population Sciences are studying social, cultural and environmental factors that are believed to be important in answering this question.


By Katrina Burton

New data released from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) shows men who took daily doses of vitamin E had significantly more prostate cancers compared to men who took a placebo.

SELECT, a cancer prevention trial funded by the National Institutes of Health (NIH), closed in September 2008, with initial findings indicating no reduction in the risk of prostate cancer for participants using selenium or vitamin E supplements. Early results also suggested that there was a possible relationship between vitamin E and prostate cancer that might have been due to chance.

Recent findings published in the Oct. 12 issue of the Journal of the American Medical Association paint a different picture.

No benefits
Almost three years after the trial recommended that participants stop using the supplements for lack of evidence of benefit, further analysis revealed a 17 percent increase in prostate cancers among men who took vitamin E supplement compared to participants receiving a placebo.

"The findings are important because we now know for sure that there is no benefit for men who take vitamin E supplements," said Elise Cook, M.D, associate professor of Clinical Cancer Prevention and co-investigator on the study at The University of Texas MD Anderson Cancer Center. "Vitamin E does not prevent prostate cancer, and appears to not only increase the risk of prostate cancer, but in some cases it increases the risk of heart failure and mortality in patients with coronary artery disease."

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