Just as cancer treatment is becoming more tailored to better strike a patient's tumor with minimal side effects, so cancer prevention is on the path to a more personalized approach.
Scott Lippman, M.D., professor and head of MD Anderson's Department of Thoracic/Head and Neck Medical Oncology, led a plenary session on the topic at the annual meeting this week of the American Association for Cancer Research Frontiers in Prevention in Philadelphia.
"We focused on various biomarkers that predict a person's cancer risk or response to a preventive intervention that are in clinical trials or are very close to clinical trial," Lippman says.
Lippman cited a model of head and neck cancer risk prediction that combines behavioral and medical history factors with genetic variations associated with susceptibility to recurrence or development of a secondary cancer. He reviewed research by Xifeng Wu, M.D., Ph.D., professor in MD Anderson's Department of Epidemiology, and colleagues that has honed the model's predictive ability by steadily adding single-point genetic variations that are linked to a patient's vulnerability to recurrence or a new cancer.
"We are moving toward having the ability to put individuals in specific risk groups that reflect their likelihood to benefit from an intervention, not only in chemoprevention but also with other interventions, such as smoking cessation options," Lippman says.
He covers these topics, including challenges to personalized prevention and other issues in a video podcast filmed at AACR. Lippman also is editor in chief of the AACR's journal Cancer Prevention Research.
Lippman also moderated a news briefing on the emerging science of chemoprevention Monday. That podcast also is available from AACR.
The Emerging Science of Chemoprevention
Moderated by Scott Lippman, M.D., editor-in-chief of Cancer Prevention Research and professor and chair in the Department of Thoracic/Head and Neck Medical Oncology at The University of Texas MD Anderson Cancer Center.
Links to releases about work presented at the AACR briefing: