OncoLog: MD Anderson's report to physicians about advances in cancer care and research.

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From OncoLog, June 2011, Vol. 56, No. 6

Selected Research and Clinical Milestones at MD Anderson 1941–2011

1941
Texas Governor W. Lee “Pappy” O’Daniel signs legislation authorizing the creation of a cancer hospital as part of The University of Texas System.

1944
MD Anderson treats its first patient.

1950
Researchers design and test the first cobalt-60 radiation therapy unit.

1951
Some of the world’s first psychological research and counseling programs for cancer patients begin at MD Anderson.

1956
The first issue of MD Anderson’s newsletter to physicians, now named OncoLog, is published.

1964
Vincristine becomes the first successful chemotherapy for children with inoperable Wilms tumors.

1966
Surgeons begin performing limb-sparing surgery for extremity tumors.

1966
MD Anderson is the first cancer hospital in the U.S. to install “life islands” to protect immunocompromised patients against infections.

1970

C-banding enables scientists to pinpoint the precise location of genes on various chromosomes.

1975
A clinical protocol for vinblastine and bleomycin becomes the first chemotherapy regimen to offer complete remission for patients with testicular cancer.

1976
MD Anderson opens the first Department of Dental Oncology in the U.S.

1976
Clinical studies demonstrate that lumpectomy followed by radiation therapy is as effective as radical mastectomy for breast cancer treatment.

1976
A clinical trial of the mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) regimen for treatment of pediatric patients with brain tumors begins.

1981
The Department of Urology establishes a Section of Sexual Rehabilitation—the first of its kind—to help patients maintain intimacy following cancer treatment.

1985
The first clinical use of liposomes to deliver targeted drug therapy is reported.

1987
Researchers adapt the polymerase chain reaction test to detect lymphoma cells in concentrations as low as 1 lymphoma cell per 1 million blood cells.

1988

MD Anderson opens the country’s first operating room equipped with a linear accelerator to deliver intraoperative radiation therapy.

1988
A landmark study establishes the benefits of administering chemotherapy to shrink breast tumors before surgery and radiation therapy.

1993
Surgeons establish the benefit of surgical resection of multiple brain metastases in some patients.

1997
Researchers pioneer the use of reduced chemotherapy doses for patients also requiring stem cell transplantation, resulting in lower mortality rates.

1997
A miniature multileaf collimator to more precisely shape radiation therapy beams is designed at MD Anderson.

2003
An epidermal growth factor receptor VIII peptide vaccine is developed to treat cerebral tumors.

2005
Researchers report initial clinical results of berubicin, the first blood-brain barrier–penetrating anthracycline for treatment of brain tumors, which was discovered and developed at MD Anderson.

2006
Researchers establish the effectiveness of dasatinib and nilotinib against imatinib-resistant chronic myelocytic leukemia.

2006
MD Anderson opens the largest proton therapy center in the U.S.

2007
Researchers demonstrate the efficacy of intensity-modulated radiation therapy against several types of cancer.

2007
A clinical trial of lenalidomide plus dexamethasone for patients with relapsed multiple myeloma leads to FDA approval of lenalidomide.

2008
Stereotactic body radiation therapy is shown to be an effective treatment for some lung cancer patients.

2009
Researchers report a successful phase III clinical trial of a therapeutic vaccine for follicular lymphoma.

2011
Results from BATTLE, a clinical trial of four drugs (each targeting a different signaling pathway), support the use of biomarkers and personalized therapy for lung cancer.

2011
A phase II study demonstrates that proton therapy with chemotherapy can reduce radiation-related toxicity compared with conventional photon treatment.

For more information, talk to your physician, visit www.mdanderson.org, or call askMDAnderson at 877-632-6789.

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